Sunday, February 16, 2020
The Prevalence of Diabetes Mellitus in the Middle East - Essay Example Non-insulin-dependent diabetes mellitus (NIDDM) increases considerably the risk for all manifestations of atherosclerotic vascular disease, coronary heart disease, cerebrovascular disease, and peripheral vascular disease(Payorala, 1987) The underlying mechanisms for accelerated atherogenesis in NIDDM are poorly understood. Although NIDDM is associated with a clustering of risk factors favoring atherogenesis (high total triglyceride and low high-density lipoprotein cholesterol levels and a high prevalence of hypertension and obesity), population-based, prospective studies have repeatedly shown that only a small proportion of the excess risk for coronary heart disease in NIDDM can be explained by the effects of NIDDM on the levels of cardiovascular risk factors(Payorala, 1987) Therefore, the excessive occurrence of coronary heart disease and other cardiovascular complications in NIDDM must be mainly caused by diabetes itself or factors related to it. Type 2 diabetes is the most prevale nt form of diabetes and is due to the combination of insulin resistance and defective secretion of insulin by pancreatic b-cells. (Grundy, Benjamin, Burke, Chait, Eckel , Howard, Mitch, Smith , & Sowers.,1999)Diabetes mellitus is a major risk factor for morbidity and mortality due to coronary heart disease (CHD), cerebrovascular disease, and peripheral vascular disease. Metabolic control and duration of type 2 diabetes are important predictors of coronary heart disease (ischaemic heart disease. (Kuusisto J, Mykkanen L, Pyorala K, & Laakso M.,1994) Introduction/Background to the issue: During the past 20 years, major socio-demographic changes have occurred in the Eastern Mediterranean Region (Alwan A, King H , 1992) The total population of the Region has almost doubled. The birth rate has remained high but infant and childhood mortality rates and the crude death rate have decreased. Life expectancy has improved dramatically, urbanization has occurred and per capita income has increased. The
Sunday, February 2, 2020
Application of M-commerce in Human Resource Management - Essay Example Mobile commerce is one such evolving areas of technology that is gaining lot of attention these days. It is a concept that is fast growing and is adopted in all types of business environment in order to get efficient as well as thorough results. Mobile commerce which is most commonly known as M-Commerce is the capability to carry on with any particular business transaction or commerce by making use of the mobile devices which includes that of mobile phones, smart phone, Personal Digital Assistant of PDA as it is commonly known as, and other such evolving technological equipments like that of the latest dash top mobile phone device. If one wants to get deeper into mobile commerce then it would be any sort of transactions which includes that of rights of ownership on a specific goods or services and the entire process of initiation or completion of the commercial activity should be carried out by making use of the mobile phone (Mennecke B 2003). Everything right from purchase to that o f selling of the products and services are now carried out using a mobile device. Some of the most common areas of services includes mobile banking, mobile brokerage, participating in auctions, mobile purchase facility and that of mobile marketing and advertising activity. The impact that mobile commerce is having over human resource management is very wide. In order to make a business model successful, adequate care and attention needs to be paid to that of the human resource management which is the crux of any organizationsÃ¢â¬â¢ growth. Proper human resource management serves to be the winning formula. In this ever growing world, things get more advanced and complicated. Human resource area needs extra effort and there should be proper line of communication and well thought out approach. The best would be to act quickly on any human resource related issues which act as the pillar of confidence for the business (Stair R 2012). Using mobile commerce technology for managing human resource is the only best way to gain what one wants to. Everything right from regular checkups, accounting, resource allocation, tracking the performance of the individual can be carried out using a mobile commerce service. There are several types of platforms and functions that are released which makes the application of mobile commerce in human resource management a valuable asset for better managements and success of the business. An organization is a combination of many things and the responsibility levels are higher. There are many essential aspects to look for in an organization and it should be properly managed in order to derive high performance (Xu J 2009). In the recent times, there are many sort of mobile commerce devices that are evolving big time. The mobile device is connected to the computer network directly and all of the information regarding the resources can be accessed directly. The mobile commerce facility in mobile phone not only provide with the ability to ac cess the available materials in common network but also offers with the capacity to make any changes or take actions directly. Human resource field is a wide area and if not properly managed or arranged it will bring in more problem to the company and business. The latest mobile device that is launched recently comes with a better facility to track each and every activity of the resources (Branki C 2008). A human resource mobile application can
Saturday, January 25, 2020
Riboflavin biosynthesis in Bacillus Subtilis Motivation: Many important problems in cell biology require the dense nonlinear interactions between functional modules to be considered. The importance of computer simulation in understanding cellular processes is now widely accepted, and a variety of simulations algorithms useful for studying certain subsystems have been designed. 1 introduction Human and animal needs vitamins and minerals to help in the growth of the body and prevent disease, obtained from food or supplements. For example, an important vitamin is riboflavin and Riboflavin is water-soluble vitamins also sources of riboflavin are milk, meat, fish, fruits and vegetables. Diets that do not contain riboflavin or poor riboflavin cause serious health problems. For example, a disorder of the digestive system, heart disease and blood vessels. Riboflavin deficiency may also cause cancer. The name riboflavin comes from ribose (the sugar whose reduced form, ribitol, forms part of its structure) and flavin, the ring-moiety which imparts the yellow color to the oxidized molecule (from Latin flavus, yellow). The reduced form, which occurs in metabolism along with the oxidized form, is colorless. Riboflavin has been used in several clinical and therapeutic situations. For over 30 years, riboflavin supplements have been used as part of the phototherapy treatment of neonatal jaundice. The light used to irradiate the infants breaks down not only bilirubin, the toxin causing the jaundice, but also the naturally occurring riboflavin within the infants blood, so extra supplementation is necessary. Riboflavin is a yellow substance which was isolated in 1879. Riboflavin name comes from ribose sugar substance and also characterized by yeast an excellent dietary source. In addition, it contains two factors which are aide Flavin adenine dinucleotide (FAD) and a Flavin mononucleotide (FMN) (Daniel, 2012). 2 Background It has been pointed out by (Bretzel, et al.1999) and recently been produced commercially by riboflavin chemical manufacturing or by fermentation, where the production of riboflavin with a purity of at least 97-98% of foodstuffs and medicines. In addition, scientists biological prefer to biological and chemical manufacturing and much more than manufacturing because of the many advantages. For example, low material cost, low waste and energy requirements due to the use of renewable energy. It has been producing a large amount of riboflavin from many organismsÃ¢â¬â¢ example of the use of fungi, yeast and bacteria Bacillus Subtilis (Li Wu, Q, 2007). Research indicated that since 30 years the worldÃ¢â¬â¢s consumption of riboflavin equivalent of 1.25 Ãâ" 106 kg per year. However, the amount of riboflavin are currently more than 3.000 tons per year (Han Lim, et al.2001). Bacillus Subtilis is a gram positive, aerobic bacteria that converts glucose directly to riboflavin. Cell metabolisms are highly dependent on environmental conditions, so the metabolic state often shifts during the cultivation period. Characterizing the transience of metabolic fluxes is important for understanding how cells responded to environmental changes. (Boyle NR, Morgan JA, 2009) Fig. 1.Riboflavin synthesis reactions As the provide chart (Riboflavin synthesis reactions) shows, riboflavin bio-product of the yeast start from Guanosine triphosphate (GTP) and there are two molecules of ribulose-5-phosphate, which leads to the production of riboflavin with enzymes encoded with RIB1, RIB2, RIB4, RIB5, RIB7 and FMN1 names which helps in the production of Flavin mononucleotide also Flavin adenine dinucleotide by enzyme FAD. Moreover, ribose involved in the production of riboflavin with 3 parts of 4-dihydroxy-2-butanone-4-P and 6 parts of 7-dimethyl-8-(1-D-ribityl) lumazine. 3 methods 3.1 In-silico (computational) model In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. (Benfenati E. and others, 2011) 3.2 Conceptual modelling Ã¢â¬â ER diagram Conceptual modeling is a way of carrying out an analysis of a system in order to identify the types of things in the system, the actual instances of those things and the relationships between those things. Entity relationship (ER) modeling is a conceptual modeling approach commonly used in Computer Science to model a domain for the development of a database. However, ER modeling provides a useful approach to starting to think about models of biological systems. 3.3 Biological network analysis and construction using Cytoscape Cytoscape platform providing a full feature set for biological network analysis. It is an open source software platform for visualizing molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data. Although Cytoscape was originally designed for biological research, now it is a general platform for complex network analysis and visualization. Cytoscape core distribution provides a basic set of features for data integration, analysis, and visualization. 3.4 Exploring integrated networks using String and Ondex The Ondex is a data integration platform which enables data from diverse biological data sets to be linked, integrated and visualised through graph analysis techniques. Ondex uses a rich and flexible core data structure, which has the ability to bring together information from structured databases and unstructured sources such as biological sequence data and free text. Ondex also allows users to visualize and analyze the integrated data. Ondex is free and open-source software. STRING is a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations. Together String and Ondex are very useful in case of exploring integrated networks and simulation. 3.5 Dynamic modeling using SBML SBML is neutral with respect to programming languages and software encoding; however, its oriented towards allowing models to be encoded using XML. By supporting SBML as a format for reading and writing models, different software tools (including programs for building and editing models, simulation programs, databases, and other systems) can directly communicate and store the same computable representation of those models. This removes an impediment to sharing results and permits other researchers to start with an unambiguous representation of the model, examine it carefully, propose precise corrections and extensions, and apply new techniques and approaches Ã¢â¬â in short, to do better science (Rhoads DG, Pring M, 1998) 3.6 RuleBender and BioNetGen and a rule-based language for modelling biochemical reactions Modern biological experiments generate large amounts of data describing intracellular dynamics. Rule-based languages for describing intracellular biochemistry allow for the construction and simulation of detailed models with unprecedented scope and precision. Rule-based Models can be used to suggest new hypotheses and new ideas for future experimentation. Rule-based models can be difficult to understand and time consuming to debug. RuleBender is a free tool for constructing, debugging, simulating and analyzing rule-based biological models in the BioNetGen language. 3.7 Flux Balance Analysis using OptFlux Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. (Jeffrey D. Orth at el, 2010). OptFlux is an open-source and modular software to support in silico metabolic engineering tasks aimed at being the reference computational application in the field. 3.8 Stochastic simulation algorithm using BioNetGen Stochastic Simulation Algorithm (GSSA) and its variants are cornerstone techniques to simulate reaction kinetics in situations where the concentration of the reactant is too low to allow deterministic techniques such as differential equations. To generate a network in advance of a simulation, which may subsequently be carried out either by numerically solving ODEs or by implementing a stochastic simulation algorithm (SSA) (Gillespie, 2007) 4 Results 4.1 Ribose and Guanosine triphosphate (GTP) The non-specific precursors of riboflavin biosynthesis which are commonly used are guanosine triphosphate and ribulose-5-phosphate. Ribose and Guanosine triphosphate (GTP) is biologically responsible for the production of riboflavin with the help of enzymes (RIB1, RIB2, RIB4, RIB5, RIB7) that catalyze reactions to produced riboflavin, with help of (FMN) to produced Flavin mononucleotide. After that, produced Flavin adenine dinucleotide (FAD). It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. It is used as a source of energy for protein synthesis and gluconeogenesis. GTP is essential to signal transduction, in particular with G-proteins, in second-messenger mechanisms where it is converted to guanosine diphosphate (GDP) through the action of GTPases. Rib A helps stimulate the production of riboflavin and direct link between the other proteins. In addition, is responsible for the outputs of the biochemical processes. Fig. 2.Rib A Simulation Fig. 3. Metal Phosphate Simulation Metal Phosphate, which is linked to a protein. Motivating force proton transfer of phosphate is associated. Thus, the transfer of the phosphate group of phosphate, ATP to amino acids. In conclusion, it is easy to extract the pure biological industries inexpensive and riboflavin without toxic substances. Therefore, it is expected in the future production of large amounts of riboflavin and faster by yeasts and fungi away from harmful chemicals. 4.2 Dynamic modelling of Riboflavin biosynthesis in Bacillus subtilis using SBML Riboflavin synthase catalyzes the transformation of 6,7-dimethyl-8-ribityllumazine into riboflavin in the last step of the riboflavin biosynthetic pathway. Gram-negative bacteria and certain yeasts are unable to incorporate riboflavin from the environment and are therefore absolutely dependent on endogenous synthesis of the vitamin. (Markus F. et at, 204) Provided a strategy for developing and implementing genome-scale metabolic models. Simultaneous growth and riboflavin overproduction using Bacillus subtilis were investigated using Michaelis-Menten enzyme reaction model using different modern software packages for computer biochemical systems simulation. Fig. 4.Riboflavin Wild Type Simulation of Riboflavin biosynthesis in Bacillus subtilis After re-simulating Riboflavin level has been changed. The added reactions corresponds to a sharper transition of riboflavin level from the beginning of the simulated riboflavin function. Fig. 5.Riboflavin Wild Type Simulation of Riboflavin biosynthesis in Bacillus subtilis 4.3 RuleBender and BioNetGen Riboflavin simulation Rule-based modeling involves the representation of molecules as structured objects and molecular interactions as rules for transforming the attributes of these objects. Fig. 6.Simulation of Riboflavin biosynthesis in Bacillus subtilis using RuleBender The approach allows systematic incorporation of site-specific details about protein-protein interactions into a model for the dynamics of cell regulatory networks, including processes involving cell signaling, gene regulation, and metabolism. The consequences of protein-protein interactions are difficult to specify and track with a conventional modeling approach because of the large number of protein phosphoforms and protein complexes that these interactions potentially generate. Here, we demonstrate how a rule-based model is specified in the BioNetGen language (BNGL) using the RuleBender interface and demonstrate how models can be visualized, simulated, and analyze. 4.4 Riboflavin Flux Balance Analysis Provided a strategy for developing and implementing genome-scale metabolic models. Calculated Synthesis and Biomass Flux values. Simultaneous growth and riboflavin overproduction using Bacillus Subtilis were investigated using Michaelis-Menten enzyme reaction SBML model and OptFlux Software Platform for Metabolic Engineering. Fig. 7.Wild Type Simulation of Riboflavin biosynthesis in Bacillus subtilis using OptFlux Fig. 8.Riboflavin Synthesis and Biomass Flux Values 4.5 Using the SSA with BioNetGen Which Type of Model to use ODE or SSA? At low molecule numbers: use stochastic model. At high molecule numbers: both types of simulation can be used, but SSA might require more Ã¢â¬Å"computing powerÃ¢â¬ than the ODE simulation. When the number of molecules is high SSA behaves like ODE. A chemical reaction model can be converted into a set of ordinary differential equations (ODEs) using the law of mass action. This law states that the rate of a reaction is its rate constant times the concentration of the reactants raised to the power of their stoichiometry. A better method for reasoning about genetic circuits is to utilize GillespieÃ¢â¬â¢s stochastic simulation algorithm (SSA) (Gillespie, 1977). There are several variants of the SSA. This paper uses the direct method, which is shown in Algorithm 1. The SSA takes a chemical reaction network model, M, and computes a time series simulation Ã ±. The SSA is essentially a Monte Carlo algorithm, which treats each reaction as a random event. For the SSA convert concentration to molecule number is using the formula: (1) Where is number of molecules, is concentration, is the AvogadroÃ¢â¬â¢s constant and is cell volume. AvogadroÃ¢â¬â¢s constant = 6.221023 Table 2. Riboflavin Enzymes convert concentration to molecule number |Enzyme| Value C Value n R5P 5e-07 5 RibA 2e-07 2 D2B4P 5e-07 5 RibH 5e-07 5 RibE 2e-07 2 Fig. 9. Simulating Riboflavin using the SSA with BioNetGen Fig. 10. Simulating Riboflavin using the SSA with BioNetGen CONCLUSION Provided a strategy for developing and implementing genome-scale metabolic models. Calculated synthesis and biomass flux values. Simultaneous growth and riboflavin overproduction using Bacillus Subtilis were investigated using Michaelis-Menten enzyme reaction SBML. An in-silico model of riboflavin biosynthesis in B. subtilis has been successfully developed. Designed the strategy for efficient producing of riboflavin in B. subtilis. The Riboflavin biosynthesis modeling has done using stochastic simulation algorithm. Presented methodology of Riboflavin biosynthesis modeling simulation using such software complexes as: RuleBender and BioNetGen, OptFlux, String and Ondex. Designed dynamic modelling of Riboflavin biosynthesis in Bacillus subtilis using SBML language. References Benfenati E., Oonella Diaza R., Cassano A., Pardoe S., Gini GM Mays C., KnaufR., Benighaus L. (2011) The acceptance of in silico models for REACH: Requirements, barriers, and perspectives, Chemistry Central Journal, Vol 5, pp 58. http://joumal.chemistry central com/content/5/1/58. Boyle NR, Morgan JA (2009) Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii. BMC Syst Biol 3: 4 Bretzel, W Schurter, W Ludwig B, Kupfer, E Doswald, S Pfister, M van Loon, A (1999). Commercial riboflavin production by recombinant Bacillus Subtilis: down-stream processing and comparison of the composition of riboflavin produced by fermentation or chemical synthesis. Journal of Industrial Microbiology and Biotechnology. Issue 1, pp 19-26. Chem. 58, 36-57 Feng X, Xu Y, Chen Y, Tang YJ (2012) Integrating flux balance analysis into kinetic models to decipher the dynamic metabolism of Shewanella oneidensis MR-1. PLoS Comput Biol 8: e1002376 Gillespie, D. T. (1977). Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81, 2340Ã¢â¬â2361. Gillespie, D. T. (2007) Stochastic simulation of chemical kinetics. Annu. Rev. Phys. Han Lim, S Soo, J Enoch, Y. (Ed.) (2001). Microbial Production of Riboflavin Using Riboflavin Overproducers, Ashbya gossypii, Bacillus Subtilis, and Candida famate: An Overview. Jeffrey D Orth, Ines Thiele, and Bernhard ÃËPalsson. What is flux balance analysis? Nature biotechnology, 28(3):245Ã¢â¬â 8, March 2010. Li Wu, Q Chen, T Gan, Y Chen, X Ming Zhao, X (2007). Optimization of riboflavin production by recombinant Bacillus Subtilis RH44 using statistical designs. Applied Microbiology and Biotechnology. Issue 4, pp 783-794. Markus F., Werner R., Sabine S., Boris I., Gerald Richter, Felix R., Wolfgang E., Adelbert B. (2004) Ã¢â¬Å"Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin.Ã¢â¬ , J. Biol. Chem., vol. 279, no. 35 Rhoads DG, Pring M. The simulation and analysis by digital computer of biochemical systems in terms of kinetic models. IV. Automatic derivation of enzymic rate laws. J Theor Biol. 1998 Sep;20(3):297Ã¢â¬â313. Sauer U., Hatzimanikatis V., Bailey J.E., Hochuli M., Szyperski T., WÃ ¼thrich K. (1997) Metabolic fluxes in riboflavin-producing Bacillus subtilis. Nat. Biotechnol. 15, 448Ã¢â¬â452. Stolz, J (2012). Riboflavin. http://www.nutrition.tum.de/index.php?id=115L=1 (29oct. 2014). 1 [*]To whom correspondence should be addressed.
Friday, January 17, 2020
In the Caribbean, specifically Jamaica, during the year of 1900-1929 there were two poets whose work truly stood out and made a statement. Those poets were Thomas Redcam (1870-1933) and Claude McKay (1878-1972). Thomas Redcam was a Jamaican poet who came from Irish ancestry. Throughout his life he promoted Jamaican literature and was a notable poet. He was seen as helpful and encouragement to younger poets during that time period including Claude McKay. Both poets had such a love for their country and made it clear in their poems. They spoke about the beauty of Jamaica, how through thick and thin Jamaica would always be their heart and homeland. The themes of nature, faith, and love are very present within the six poems we read. In Thomas RedcamÃ¢â¬â¢s poem Ã¢â¬Å"My Beautiful HomeÃ¢â¬ is where we first see the predominant themes of nature, faith, and love. In this poem he speaks of Jamaica in such vivid terms, making mention of the land only using words such as beautiful. He al so speaks of how the beauty of his homeland is the main reason he loves his land. He speaks of this love as being like none other, a love that is strong and rooted in heart and faith. He makes the idea clear that even when not there his love will always be there and living strong Ã¢â¬Å"Whenever I wander, for thee my love is abiding and strongÃ¢â¬ (Redcam, 45). This idea for love of country and nature continues in his next poem Ã¢â¬Å"OÃ¢â¬â¢little Green Island. Far Over the SeaÃ¢â¬ In this poem he speaks of the English rule throughout Jamaica and how it affects the people in one aspect but not at all in the other. Not once does he speak negatively about England but rather Redcam glorifies and praises their rule, Ã¢â¬Å"For England is England, brave, patient, and true.Ã¢â¬ (Redcam, 46) He speaks of how no matter who is ruling they are themselves and their love will always be for their own land Jamaica, Ã¢â¬Å"But my little Green Island, far over the sea, At eve-tide Jamaica, my heart turns to thee.Ã¢â¬ (Redcam, 46). Redcam makes it clear through his statement that living under the English rule does not change them but rather strengthens their love for their own homeland, Jamaica. Lastly but not least once again the themes of love and nature continue in RedcamÃ¢â¬â¢s last poem, but the theme of faith also becomes present in Ã¢â¬Å"JamaicaÃ¢â¬â¢s Coronation OdeÃ¢â¬ . Here more than in his other poems we find the idea of love for the country and how our love along with the idea of a strong faith helps us stand true to our country. He speaks of the war and hard times the people of Jamaica went through during this time period and although he speaks of hardship not once does he mention the idea of negativity. He speaks of positive thoughts and how their love and faith in Jamaica will carry them through the war and as a matter of fact anything in life. He speaks positive thoughts of the moving forward and the future to come after the war Ã¢â¬Å"We are marching to conquer the Future, We are sons of Jamaica the free, We are true to our King and our Country, We are heirs of the ages to beÃ¢â¬ (Redcam, 47) . This quote is mentioned throughout the poem which really shows the true faith and how they truly believed they could conquer it all with their strong love for Jamaica. Although in this poem the idea of faith in love is more predominant Redcam still mentions the nature he always speaks so highly of. A few years after the poems of Redcam came those of Claude McKay. Claude McKay was a Jamaican- American poet who inspired and guided by the work of Redcam. He was the author of four novels during the time of the Harlem Renaissances. During that time he also wrote short stories and poems, which he is noted for all around the world. McKay being under the guidance of Redcam had the same predominant themes in his poems which were that of nature, love, and faith. In McKayÃ¢â¬â¢s first poem Ã¢â¬Å"My Native Home LandÃ¢â¬ the theme of love is instantly noticeable. He speaks of his love and how he feels Jamaica has made him the man he is. He speaks of how through thick and thin he will stand by his country and defend her. Ã¢â¬Å" Though you casÃ¢â¬â¢ me from your breasÃ¢â¬â¢ AnÃ¢â¬â¢ trample me to deaf; My heart will trusÃ¢â¬â¢ you none de less, My land I wonÃ¢â¬â¢t forgetÃ¢â¬ (McKay, 64). McKay makes it clear that he will never lose his faith in Jamaica as well. In this poem Jamaica McKay believes that his country Jamaica is one that can do no wrong. Once again the ideas of nature, faith and love continue in his next poem Ã¢â¬Å"Flame HeartÃ¢â¬ but this time the idea of nature becomes the more predominant one. In this work Mckay speaks how he returns back to Jamaica. Throughout the poem he mentions aspects of nature in the land that he can not recall but then mentions the one part of the land he remembers so vividly. McKay speaks of poinsettia plants he remembers so well. He speaks of their beauty and color, Ã¢â¬Å"I have forgotten much, but I still remember The poinsettiaÃ¢â¬â¢s red, blood-red in warm DecemberÃ¢â¬ (McKay, 70). He speaks so vividly of this one aspect of nature and not only does he mention the beauty of it, he dives even deeper when mention of climate comes in. This statement about the poinsettia is mentioned a few times in the poem giving off a strong vibe and conviction. Everything to the speaker is a blur but through his blurs he is able to remember that red-blood poinsettia plant in warm December month. In his last poem Ã¢â¬Å"I Shall ReturnÃ¢â¬ McKay touches upon all three themes in such strong points. This poem speaks of someone who has left Jamaica but has intentions of returning. It speaks of how their love for their country has encouraged them to return, but also their faithfulness. It speaks of how they truly miss the nature and beauty of their homeland. The speaker believes that when they return they will save themselves pain. Ã¢â¬Å"I shall return, I shall return again, to ease my mind of long, long years of painÃ¢â¬ (McKay, 71). Jamaica is their home and they feel it is where they belong no matter where life takes them. Their faith and love will always bring them back home. These 6 poems are the perfect example of the three themes mentioned. Not one of them speaks of negative thoughts of Jamaica but instead glorifies all its beauty and the faith and love the Jamaican people truly have for their land. Both poets have such strong and impacting words when speaking of their land and truly believe that there is no land like theirs. They speak from the heart and truly give their readers vivid ideas of what things were like. These poets are have left a good impact on not only the people of their homeland but of people around the world through their poems. Works Cited Donnell, Alison, and Sarah Lawson Welsh. Routledge Reader in Caribbean Literature. London: Routledge, 1996. Print.
Thursday, January 9, 2020
The relationship of free speech to that of hate groups, and the protection of hate speech under the first Amendment is a much debated topic of ethics and civil liberties. Although affirmative action protects against discrimination of race, religion, gender, and disabilities, it only protects from discrimination in educational institutions and employment. So how can a society that claims to protect civil rights allow the production of speech that opposes those same fundamental rights?, because this form of speech, although hateful in nature, are ideas, and Ã¢â¬Å"hateful ideas are just as protected under the First Amendment as other ideasÃ¢â¬ (McGough, 2015). The First Amendment guarantees freedoms in regards to expression, religion, assembly, and the right to petition. Freedom of expression prohibits Congress from restricting the press or individuals the right to speak freely (Legal Information Institute, n.d.). A hate group, as stated by Walker Bragman, is Ã¢â¬Å"an organized group or movement that advocates and practices hatred, hostility, or violence towards members of a race, ethnicity, religion, gender, sexual orientation or other designated sector of societyÃ¢â¬ (Bragman, 2012). Speech that attacks, demeans, threatens, or insults a person or group on the basis of origin, ethnicity, religion, gender, gender identity, sexual orientation or disability is identified as hate speech (Random House Dictionary, 2016). By design the First Amendment was established to protect unpopular speech,Show MoreRelatedHate Speech And Freedom Of Speech1393 Words Ã |Ã 6 Pages In the name of free speech, hate speech should not be tolerated. Hate speech has devastating effects on the people and communities it is targeted at. Left unchecked hate speech can lead to harmful and violent effects. Over the past few years, the effects of hate speech used on women, homosexuals, ethnic groups and religious minorities have become more and more apparent. Hate speech can be very divisive in many of the situations it is used, depending on who interprets the expression can vary howRead MorePersuasive Essay On Hate Speech1612 Words Ã |Ã 7 Pages In the name of free speech, hate speech should not be tolerated. Hate speech has devastating effects on the people and communities it is targeted at. Left unchecked hate speech can lead to harmful and violent effects. Over the past few years, the effects of hate speech used on women, homosexuals, ethnic groups and religious minorities have become more and more apparent. Hate speech can be very divisive in many of the situations it is used, depending on who interprets the expression can vary ho wRead MoreHate Speech Should Be Made Illegal1351 Words Ã |Ã 6 PagesÃ¢â¬Å"GOD HATES FAGSÃ¢â¬ is the kind of hate speech used by the members of Westboro Baptist Church to grab headlines and national attention. The public backlash against them has been almost universal. The public opinion that it is reprehensible and unnecessarily hurtful is at the center of the debate on whether or not some hate speech should be made illegal. An interesting side effect is it can have a polarizing effect for good. It can bring people together to stand up against the person or group speakingRead MoreSpeech On The Bill Of Rights1153 Words Ã |Ã 5 Pagesrespecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the pressÃ¢â¬ (Alderman and Kennedy, pg.21). 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Public andRead MoreFreedom Of Expression Under Charter Framework1643 Words Ã |Ã 7 PagesAnother important Supreme Court case that examined the reasonable limits on freedom of expression is R v. Whatcott. The Whatcott ruling also c hallenged the jurisdictional issues of free speech. William Whatcott, a Christian activist who advocated strongly against homosexuality and same sex marriage. Whatcott distributed several flyers in Saskatchewan that discussed political, social and moral issues. Many of these flyers heavily denouncing homosexuality using strong offensive language denouncingRead MoreProtecting The Rights Of Minority Groups1538 Words Ã |Ã 7 Pagesharmed by hate speech. As a result of competing rights, the state often faces the difficult task of determining when one right trumps the other. In this essay, I will discuss and defend the reasons why we must restrict certain types of hate speech Ã¢â¬â the kind that assaults our dignity, and is harmful. Moreover, I will discuss and defend why we must protect the rights of minority groups, and how doing so can contribute to the greater good of society. To protect the rights of minority groups, governmentsRead More Hate Crime Laws Essay1378 Words Ã |Ã 6 PagesI strongly support hate crime laws. Now, before I dive into this very controversial subject, I should probably define what hate crime laws are so you will have a better understanding of what I am talking about. As I have understood it, hate crime laws are laws that protect certain minorities or groups from bias motivated violence and harassment, and also more harshly punish people that commit these crimes against them. As I started to do my research on hate crime laws I beganRead MoreFreedom of Speech in America and Its Limits Essay2413 Words Ã |Ã 10 Pagesdemocratic nations in the world, the United States has had its own fair share of issues with hate speech. There has been a lot of controversy over whether hate speech should be regulated. In analyzing the concept of free speech, one cannot ignore that it does not occur in a vacuum. There have been all types of debasements ranging from ethnic, religious, racial and gendered stereotyping. Freedom of speech inherently includes all other fundamental human rights. Hence, as acknowledged through naturalRead MoreHate Speech1536 Words Ã |Ã 7 PagesHate Speech Essay In the first amendment of the United States constitution, American citizens are guaranteed the right to free speech. This is a fundamental right of American law, and one of the foundations of the U.S. Constitution. It is also the breeding ground for one of the most widely debated issues in America: What, if any, measures should be put into place to regulate hateful language? Most people will agree under one definition or another that hate speech is a socially deviant activity
Wednesday, January 1, 2020
Concatenation in the Java programming language is the operation of joining two strings together. You can join strings using either the addition () operator or the StringÃ¢â¬â¢s concat() method. Using the Operator Using the operator is the most common way to concatenate two strings in Java. You can provide either a variable, a number, or a String literal (which is always surrounded by double quotes). To combine the strings Ã¢â¬Å"IÃ¢â¬â¢m aÃ¢â¬ and Ã¢â¬Å"studentÃ¢â¬ , for example, write: IÃ¢â¬â¢m a student Be sure to add a space so that when the combined string is printed, its words are separated properly. Note above that student starts with a space, for example. Combining Multiple Strings Any number of operands can be strung together, for instance: IÃ¢â¬â¢m a student ! And so are you. Using the Operator in a Print Statement Frequently, the operator is used in a print statement. You might write something like: System.out.println(pan handle); This would print: panhandle Combining Strings Across Multiple Lines Java disallows literal strings to span more than a line. Using the operator prevents this: String quote Nothing in all the world is more dangerous than sincere ignorance and conscientious stupidity.;Ã Combining a Mixture of Objects TheÃ operatorÃ normally acts as anÃ arithmetic operatorÃ unless one of itsÃ operandsÃ is a String. If so, it converts the other operand to a String before joining the second operand to the end of the first operand. For example, in the example below, age is an integer, so the operator will first convert it to a String and then combine the two strings. (The operator does this behind the scenes by calling its toString() method; you wonÃ¢â¬â¢t see this occur.) int age 12;System.out.println(My age is age); This would print: My age is 12 Using the Concat Method The String class has a method concat() that performs the same operation. This method acts on the first string and then takes the string to combine as a parameter: public String concat (String str)Ã¢â¬â¹Ã For example: String myString I have decided to stick with love.;myString myString.concat( Hate is too great a burden to bear.);System.out.println(myString); This would print: I have decided to stick with love. Hate is too great a burden to bear. Differences Between the Operator and the Concat Method You may be wondering when it makes sense to use the operator to concatenate, and when you should use the concat() method.Ã Here are some differences between the two: The concat() method can combine only String objects Ã¢â¬â it must be called on a String object, and its parameter must be a String object. This makes it more restrictive than the operator since the operator silently converts any non-string argument to a string.The concat() method throws a NullPointerException if the object has a null reference, while the operator deals with a null reference as a Ã¢â¬Å"nullÃ¢â¬ string.The concat()) method is capable of combining only two strings Ã¢â¬â it cannot take multiple arguments. The operator can combine any number of strings. For these reasons, the operator is more often used to combine strings. If you are developing a large-scale application, however, performance can differ between the two because of the way that Java handles string conversion, so be aware of the context in which you are combining strings.
Tuesday, December 24, 2019
What is disciplinary literacy in the history classroom? What are the specific literacy strategies/skills students need in the history classroom? What are the demands of the disciplinary literacy in the history classroom? What does the history teacher need to know to develop disciplinary literacy in her/his classroom? How to develop disciplinary literacy skills in the history classroom? Bain, R. B. (2012). Using disciplinary literacy to develop coherence in history teacher education: The clinical rounds project. The History Teacher, 45(4), 513 - 532. Bain (2012) defines disciplinary literacy in history as the necessary connections to improve the teachers capabilities to use reading and writing in history across different contexts and in a range of learners. Bain (2012), based on Mojes s findings, claims that there are four identified interconnected skills of funds of knowledge: semantic, disciplinary, discursive, and pragmatic knowledge. Historians read, interpret, and analyze to create narratives, explanations, or arguments. According to Bain (2012), the traditional strategies of sourcing, contextualizing, or corroborating do not fully capture the reading support that students need to understand the different genre, positions, and type of historical texts. There are greater demands for adolescents in reading and writing. The text complexity of the history texts in middle and high schools demand from students in these grades toShow MoreRelatedQuestions On Increasing Disciplinary Reading986 Words Ã |Ã 4 Pages1. Increasing Disciplinary Reading Biancarosa (2012) states in the introduction to this section that as students progress up through the grades their reading in content-area courses becomes progressively more distinct (p. 47). A student in a fourth grade science course will encounter different terminology in a fourth grade social studies course and even more diverse terminology by the time they reach high school biology. However, I have often found, and Biancarosa (2012) as acknowledges that manyRead MoreHow Sex Differences Affect My Middle School Teaching1389 Words Ã |Ã 6 Pagesstudents. Throughout this paper I will outline what I have learned about sex differences in learning and how this will be applied to the classes I teach. After reading Doreen KimuraÃ¢â¬â¢s book, Sex and Cognition, I got to wondering how the sex differences that she outlined could be used to better understand the ways that my middle school students learned. There were a few findings that stuck out from her research that I felt applied directly to my classroom. One of those findings was the difference inRead MoreUsing Online Literacy Software Programs1562 Words Ã |Ã 7 Pagesstudy and discover whether the online digital programs being used in the classroom help ELLs master the academic vocabulary to understand advanced texts. Given these facts, the researcher has proposed himself to focus his action research on the following question: Will the ELLs improve their comprehension skills of expository texts by focusing most of their practices on vocabulary development through the use of online literacy software programs? Review of the Literature English language learners (ELLs)Read MoreLearning Using A Whole Class1094 Words Ã |Ã 5 Pageswriting to think historically and better understand the past. Disciplinary thinking and improving literacy were essential for Mr. Lyle. By integrating writing to learn strategies as well as reading historical documents for context, Mr. LyleÃ¢â¬â¢s students were using historical reasoning which in turn promoted his students reading, writing, and thinking skills. Mr. LyleÃ¢â¬â¢s approach helped Ã¢â¬Å"students understand content, promote disciplinary thinkingÃ¢â¬ , and the skills needed for his studentÃ¢â¬â¢s future careersRead MoreClassroom Climate Is The Focus Of Education Issues921 Words Ã |Ã 4 Pagesinvestigation about classroom climate is the focus of education issues. Large number of educators are exploring through a variety of disciplinary perspectives and diverse research methods. With the arrival of technology and the ecological trend of educational development, class room climate is becoming a new perspective and path of classroom study. In the Article Exploring the Relationship between Classroom Climate, Reading Motivation, and Achievement: A Look into 7th Grade Classrooms, the authors MucherahRead MoreEll Shadowing Case Study960 Words Ã |Ã 4 Pagesteachers will participate in determining what actions could be taken to better educate ESL students. The mechanics of the program would involve teachers accompanying ESL students to their classes for two to three hours and, at five-minute intervals, noting briefly what the primary action of the ESL student is (e.g., listening, talking, etc). This monitoring is not a travel log of the studentÃ¢â¬â¢s activities during the day, but, rather, notes of the type that can be summarized into data points (Soto,Read MoreThe Nature Of Teaching And Learning1682 Words Ã |Ã 7 Pagesstates/territoriesÃ¢â¬â¢ education ministers. The goals were set in the context of a 21st century Australia being able to compete in the global economy on knowledge and innovation. The Declaration stressed the development of skills in social interaction, cross-disciplinary thinking, the use of digital media as well as the national values of Ã¢â¬Å"democracy, equity and justice, and personal values and attributes such as honesty, resilience and respect for othersÃ¢â¬ (p 2). The Declaration set out two main goals: 1. AustralianRead MoreMy Experience With English Language Learners Essay1397 Words Ã |Ã 6 Pageseducator, it is important for me to make my classroom a great learning environment for all of my students. Growing up, I would always enjoy hands-on activities in the classroom. I remember looking forward to different holidays because we would be able to participate in an arts and crafts activities while being able to learn about the holiday we were celebrating. Until I started learning more about English Language Learners, I never realized how these activities can be more difficult for some students. BecauseRead MoreOverview of Common Core State Standards1226 Words Ã |Ã 5 Pageswhether students were meeting those standards (Gibbs, T. Howley, A., 2000). In 1996, the nationÃ¢â¬â¢s governors and various corporate leaders founded Achieve, Inc., as a bipartisan effort to raise academic standards and graduation requirements, improve assessments, and heighten academic accountability in all 50 states (Achieve, Inc. 1996). An Achieve, Inc. 2004 report, titled, Ready or Not: Creating a High School Diploma That Counts, stated that both employers and colleges were demanding moreRead MoreThe Growth Of Literacy Skills2155 Words Ã |Ã 9 PagesLiteracy can be defined as the ability to read and write. It can also be defined as the capacity to identify, understand, create, interpret, communicate and compute, using written and printed materials associated with varying contexts. Literacy includes the capability to read, comprehend, and critically appreciate various forms of communication, including spoken language, written text, broadcast media, and digital media. The contemporary meaning has been expanded to include the knowledge to use language